[Somatostatin in breast cancer].
Identifieur interne : 012449 ( Main/Exploration ); précédent : 012448; suivant : 012450[Somatostatin in breast cancer].
Auteurs : Albane Frati [France] ; Martine Antoine ; Anita Rodenas ; Joseph Gligorov ; Roman Rouzier ; Elisabeth ChéreauSource :
- Annales de biologie clinique [ 0003-3898 ]
Descripteurs français
- KwdFr :
- Antinéoplasiques hormonaux (usage thérapeutique), Détection précoce de cancer, Femelle, Humains, Lymphadénectomie (effets indésirables), Lymphoedème (), Lymphoedème (étiologie), Mastectomie (effets indésirables), Résultat thérapeutique, Somatostatine (analogues et dérivés), Tumeurs du sein (), Tumeurs du sein (diagnostic), Tumeurs du sein (traitement médicamenteux).
- MESH :
- analogues et dérivés : Somatostatine.
- diagnostic : Tumeurs du sein.
- effets indésirables : Lymphadénectomie, Mastectomie.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Antinéoplasiques hormonaux.
- étiologie : Lymphoedème.
- Détection précoce de cancer, Femelle, Humains, Lymphoedème, Résultat thérapeutique, Tumeurs du sein.
English descriptors
- KwdEn :
- Antineoplastic Agents, Hormonal (therapeutic use), Breast Neoplasms (diagnosis), Breast Neoplasms (drug therapy), Breast Neoplasms (surgery), Early Detection of Cancer, Female, Humans, Lymph Node Excision (adverse effects), Lymphedema (etiology), Lymphedema (prevention & control), Mastectomy (adverse effects), Somatostatin (analogs & derivatives), Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Somatostatin.
- chemical , therapeutic use : Antineoplastic Agents, Hormonal.
- adverse effects : Lymph Node Excision, Mastectomy.
- diagnosis : Breast Neoplasms.
- drug therapy : Breast Neoplasms.
- etiology : Lymphedema.
- prevention & control : Lymphedema.
- surgery : Breast Neoplasms.
- Early Detection of Cancer, Female, Humans, Treatment Outcome.
Abstract
In man, somatostatin is a hormone mostly produced by hypothalamus. It plays different parts in hormonal regulation through many specific receptors in human body. It has also two interesting actions such as an anti-secretory activity, mostly on the gastrointestinal system and an antiproliferative action on tumor cells. Many synthetic somatostatin analogues, more stable than the natural one, have been developed and are already used in digestive surgery to treat postoperative digestive fistula. Also, the development of specific polyclonal antibodies allowed the identification of five specific somatostatin receptors and their localization in different cell species. The presence of the five receptors in breast cancer cells has than been demonstrated. The purpose of this literature review is to clarify the potential antitumor effect of somatastatin analogues in breast cancer; its use as a preventive agent on lymphorrhea after breast surgery and its employment in imaging for early breast cancer detection.
DOI: 10.1684/abc.2011.0588
PubMed: 21896402
Affiliations:
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Le document en format XML
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(effets indésirables)</term><term>Résultat thérapeutique</term><term>Somatostatine (analogues et dérivés)</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (diagnostic)</term><term>Tumeurs du sein (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents, Hormonal</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term><term>Mastectomy</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Somatostatine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" 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It plays different parts in hormonal regulation through many specific receptors in human body. It has also two interesting actions such as an anti-secretory activity, mostly on the gastrointestinal system and an antiproliferative action on tumor cells. Many synthetic somatostatin analogues, more stable than the natural one, have been developed and are already used in digestive surgery to treat postoperative digestive fistula. Also, the development of specific polyclonal antibodies allowed the identification of five specific somatostatin receptors and their localization in different cell species. The presence of the five receptors in breast cancer cells has than been demonstrated. The purpose of this literature review is to clarify the potential antitumor effect of somatastatin analogues in breast cancer; its use as a preventive agent on lymphorrhea after breast surgery and its employment in imaging for early breast cancer detection.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Antoine, Martine" sort="Antoine, Martine" uniqKey="Antoine M" first="Martine" last="Antoine">Martine Antoine</name><name sortKey="Chereau, Elisabeth" sort="Chereau, Elisabeth" uniqKey="Chereau E" first="Elisabeth" last="Chéreau">Elisabeth Chéreau</name><name sortKey="Gligorov, Joseph" sort="Gligorov, Joseph" uniqKey="Gligorov J" first="Joseph" last="Gligorov">Joseph Gligorov</name><name sortKey="Rodenas, Anita" sort="Rodenas, Anita" uniqKey="Rodenas A" first="Anita" last="Rodenas">Anita Rodenas</name><name sortKey="Rouzier, Roman" sort="Rouzier, Roman" uniqKey="Rouzier R" first="Roman" last="Rouzier">Roman Rouzier</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Frati, Albane" sort="Frati, Albane" uniqKey="Frati A" first="Albane" last="Frati">Albane Frati</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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